Search results for "Clinical events"

showing 10 items of 10 documents

In-hospital death and adverse clinical events in elderly patients according to disease clustering: The REPOSI study

2010

OBJECTIVE: The aim of the study was to recognize clusters of diseases among hospitalized elderly and to identify groups of patients at risk of in-hospital death and adverse clinical events according to disease clustering. METHOD: This was a cross-sectional study conducted in 38 internal medicine and geriatric wards in Italy participating in the Registro Politerapie SIMI (REPOSI) study during 2008. The subjects were 1,332 inpatients aged 65 years or older. Clusters of diseases (i.e., two or more co-occurrent diseases) were identified using the odds ratios (OR) for the associations between pairs of conditions, followed by cluster analysis. Logistic regression models were used to evaluate the …

MaleAgingDisease clustersPediatricsmedicine.medical_specialtySettore MED/09 - Medicina InternaHospital unitDiseaseHospital mortalitydisease clusteringLogistic regressionNO80 and overMedicineCluster AnalysisHumansHospital MortalityAgedAged 80 and overIn hospital deathMedical Errorsbusiness.industryClinical eventsAged; Aged 80 and over; Cluster Analysis; Female; Hospital Mortality; Humans; Italy; Male; Medical ErrorsREPOSIIn-hospital death; elderly patients; disease clustering; REPOSIIn-hospital deathOdds ratioSettore MED/45 - Scienze Infermieristiche Generali Cliniche E Pediatricheelderly patientItalyFemaleGeriatrics and Gerontologybusinesspatients at risk of in-hospital death; adverse clinical events according to disease clustering
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Prediction of long-term major events soon after a first ST-segment elevation myocardial infarction by cardiovascular magnetic resonance.

2016

Cardiovascular magnetic resonance (CMR) predicts combined clinical events in post-ST-segment elevation myocardial infarction (STEMI) patients. However, its contribution to predicting long-term major events (ME: cardiac death and non-fatal myocardial infarction [MI]) is unknown. We aimed to assess whether CMR predicts long-term MEs when performed soon after STEMI.We prospectively recruited 546 STEMI patients between 2004 and 2012. The Left ventricular (LV) ejection fraction (LVEF,%), infarct size (IS), edema, hemorrhage, microvascular obstruction, and myocardial salvage were quantified by CMR at pre-discharge. During a mean follow-up of 840 days, 57 ME events (10%; 23 cardiac deaths, 34 non-…

Malemedicine.medical_specialtyMagnetic Resonance SpectroscopyMyocardial InfarctionHemorrhage030204 cardiovascular system & hematologyTime03 medical and health sciencesVentricular Dysfunction Left0302 clinical medicineEdemaInternal medicinemedicineST segmentEdemaHumansRadiology Nuclear Medicine and imagingcardiovascular diseases030212 general & internal medicineMyocardial infarctionProspective StudiesRegistriesEjection fractionmedicine.diagnostic_testClinical eventsbusiness.industryMyocardiumReproducibility of ResultsMagnetic resonance imagingGeneral MedicineMiddle AgedInfarct sizemedicine.diseaseMicrovesselscardiovascular systemCardiologyFemalemedicine.symptombusinessCardiac deathsFollow-Up StudiesEuropean journal of radiology
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Hospital Care of Older Patients With COPD: Adherence to International Guidelines for Use of Inhaled Bronchodilators and Corticosteroids

2019

Abstract Objectives We aimed to analyze the prevalence and impact of COPD in older patients hospitalized in internal medicine or geriatric wards, and to investigate adherence to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines, associated clinical factors, and outcomes. Design Data were obtained from REgistro POliterapie SIMI (REPOSI), a prospective multicenter observational registry that enrolls inpatients aged ≥65 years. Setting and Participants Older hospitalized patients enrolled from 2008 to 2016 with a diagnosis of COPD. Measures We evaluated adherence to the 2018 GOLD guidelines at admission and discharge, by examining the prescription of inhaled bronchodi…

Malemajor clinical eventmajor clinical eventsPulmonary Disease Chronic Obstructive0302 clinical medicineOlder patientsAdrenal Cortex Hormones80 and over030212 general & internal medicineLS4_4adherenceProspective StudiesGeneral NursingNursing (all)2901 Nursing (miscellaneous)Aged 80 and overCOPDHealth PolicyGeneral MedicineCOPD guidelines adherence major clinical events older patientsolder patientsObstructive lung diseaseBronchodilator Agentsguidelines adherenceHospitalizationInhalationCOPD; guidelines adherence; major clinical events; older patients; Administration Inhalation; Adrenal Cortex Hormones; Aged; Aged 80 and over; Bronchodilator Agents; Female; Humans; Male; Prospective Studies; Pulmonary Disease Chronic Obstructive; Guideline Adherence; HospitalizationAdministrationFemaleGuideline AdherenceCOPD guidelinesCOPD; guidelines adherence; major clinical events; older patients; Nursing (all)2901 Nursing (miscellaneous); Health Policy; Geriatrics and GerontologyChronic Obstructivemedicine.medical_specialtySocio-culturalePulmonary Disease03 medical and health sciencesolder patientInternal medicineAdministration InhalationmedicineHumansCOPDMedical prescriptionAgedPolypharmacybusiness.industrySettore MED/09 - MEDICINA INTERNAOdds ratiomedicine.diseaseConfidence intervalrespiratory tract diseasesCOPD; guidelines adherence; major clinical events; older patientsObservational studyGeriatrics and Gerontologybusiness030217 neurology & neurosurgery
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Adverse Clinical Events and Mortality During Hospitalization and 3 Months After Discharge in Cognitively Impaired Elderly Patients

2012

BACKGROUND: Controversial findings are reported on hospital outcome in cognitively impaired patients. The aim of this study was to explore mortality risk according to cognitive status during hospitalization and after 3 months in elderly patients. METHODS: Sixty-six internal medicine and geriatric wards in Italy participated in the "Registry Politerapie SIMI (REPOSI)" during 2010. Of the 1,380 in-patients, aged 65 and older enrolled, 1,201 were included. Cognition was evaluated with the Short Blessed Test (SBT). Logistic regression was used to evaluate the association of questionable and impaired cognition (according to SBT cutoff points) with mortality during hospitalization and at follow-u…

GerontologyMaleARDSTime FactorsSettore MED/09 - Medicina InternaActivities of Daily Living Aged Aged; 80 and over Cognition Disorders; diagnosis/mortality Female Geriatric Assessment; methods Hospital Mortality Hospitalization; statistics /&/ numerical data Humans Intelligence Tests Italy; epidemiology Logistic Models Male Odds Ratio Patient Discharge; statistics /&/ numerical data Risk Assessment; methods Risk Factors Severity of Illness Index Time Factorsdiagnosis/mortalitycognitively impaired patients; Registry Politerapie SIMI (REPOSI); Elderly patients;Logistic regressionSeverity of Illness IndexDementia; agingRisk FactorsActivities of Daily Living80 and overOdds RatioHospital MortalityAged 80 and overIntelligence TestsAdverse clinical eventsCognitionSettore MED/45 - Scienze Infermieristiche Generali Cliniche E PediatrichePatient Dischargestatistics /&/ numerical dataHospitalizationItalyFemaleepidemiologyElderly patientmedicine.medical_specialtyelderly patientsRisk AssessmentOddsmethodsNOInternal medicinemedicineDementiaHumansRegistry Politerapie SIMI (REPOSI)Adverse effectGeriatric Assessmentcognitive functionAgedbusiness.industryagingOdds ratiocognitively impaired patientmedicine.diseasemortalityConfidence intervalhospital admissionLogistic ModelsAdverse clinical events; elderly patients; cognitive function; mortality; hospital admissionDementiaGeriatrics and GerontologybusinessCognition Disorders
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Telemonitoring in chronic pain management using smartphone apps: a randomized controlled trial comparing usual assessment against app-based monitorin…

2020

Background. The usefulness of mHealth in helping to target face-to-face interventions for chronic pain more effectively remains unclear. In the present study, we aim to test whether the Pain Monitor mobile phone application (app) is well accepted by clinicians, and can help improve existent medical treatments for patients with chronic musculoskeletal pain. Regarding this last goal, we compared three treatment conditions, namely usual treatment, usual treatment with an app without alarms and usual treatment with an app with alarms. All treatments lasted one month. The three treatments were compared for all outcomes, i.e., pain severity and interference, fatigue, depressed mood, anxiety and a…

medicine.medical_specialtyHealth Toxicology and Mutagenesismedia_common.quotation_subjectPsychological interventionlcsh:MedicineAngerArticlelaw.invention03 medical and health sciences0302 clinical medicineRandomized controlled triallawmental disordersmedicineHumansPain Management030212 general & internal medicinemHealthSalut mentalmedia_commonClinical eventsbusiness.industrylcsh:RPublic Health Environmental and Occupational HealthChronic painecological momentary assessmenttelemonitoringmedicine.diseaseMobile Applicationssmartphone appClinical AlarmsSmartphone apprandomized controlled trialPhysical therapyAnxietySmartphonemedicine.symptomChronic Painbusinesschronic pain030217 neurology & neurosurgery
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Morphology of placental villi after premature delivery and its clinical relevance

1986

Based on a new concept of maturation of the placental villous tree and its disorders (synchronous and asynchronous immaturity, asynchronous maturity, hyperpermaturity, and terminal villi deficiency) we studied the possible effect of the placental villous tree on the premature onset of labour. In mature normal neonates irregular and asynchronous villous patterns were found in 50% of cases. In prematurely delivered neonates, only 33% of the corresponding placentas show synchronous immature villous patterns. Uterine bleeding in the first trimester was associated with a 42% of incidence of premature maturation of the villous tree. These findings strengthen the idea that hormonal imbalance in ea…

medicine.medical_specialtyPregnancy High-RiskPregnancy Complications CardiovascularPhysiologyGestational AgeEarly pregnancy factorPlacental structuredigestive systemObstetric Labor PrematurePre-EclampsiaPregnancyMaldevelopmentPlacentamedicineHumansClinical significanceGynecologybiologybusiness.industryClinical eventsSmokingInfant NewbornObstetrics and GynecologyUterine bleedingGeneral MedicineFirst trimestermedicine.anatomical_structureembryonic structuresbiology.proteinLabor OnsetFemaleChorionic VillibusinessMaternal AgeArchives of Gynecology
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Predictors of clinical events occurring during hospital stay among elderly patients admitted to medical wards in Italy.

2016

Abstract Background Clinical events occurring during hospital stay are independent predictors of prolonged hospitalization, in-hospital mortality and readmission among elderly patients admitted to medical wards. Purpose To identify predictors of intercurrent clinical events (ICE) during hospital stay among the main demographic, functional and clinical characteristics assessed at hospital admission in a multicenter sample of elderly inpatients in Italy. Methods This observational prospective cohort study was conducted in 66 internal and geriatric medicine hospital wards in 2010. It enrolled 1267 inpatients aged 65 years or older living at home before hospitalization. Multivariable Poisson re…

MalePediatricsmedicine.medical_specialtySettore MED/09 - Medicina InternaFevermedicine.medical_treatmentWater-Electrolyte ImbalanceRisk AssessmentUrinary catheterizationBody Temperature03 medical and health sciencessymbols.namesake0302 clinical medicineRisk FactorsInternal MedicinemedicineOdds RatioHumans030212 general & internal medicinePoisson regressionPoisson DistributionProspective StudiesProspective cohort studyAgedGeriatricsAged 80 and overbusiness.industry030503 health policy & servicesAnemiaArrhythmias CardiacProton Pump InhibitorsOdds ratioPneumoniamedicine.diseaseComorbidityHospitalizationItalyRelative riskEmergency medicineMultivariate AnalysisUrinary Tract InfectionssymbolsElderly Intercurrent clinical events Adverse events REPOSI HospitalizationObservational studyFemale0305 other medical sciencebusinessUrinary CatheterizationImmunosuppressive AgentsEuropean journal of internal medicine
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Older age and markers of inflammation are strong predictors of clinical events in women with asymptomatic carotid lesions

2007

OBJECTIVE: Limited information exists regarding the association between markers of inflammation, such as high-sensitivity C-reactive protein (hs-CRP) and fibrinogen, and adverse events in postmenopausal women with subclinical atherosclerosis. Therefore, we investigated the prognostic impact of traditional risk factors and inflammation on adverse cardiac events in women with asymptomatic carotid lesions. DESIGN: We studied 250 postmenopausal women who were free of cardiovascular disease. Traditional cardiovascular risk factors were investigated, and laboratory analysis included measurement of plasma lipids, fibrinogen, and hs-CRP. The early phases of carotid atherosclerosis were assessed by …

Adultmedicine.medical_specialtyPathologySettore MED/09 - Medicina Internaclinical eventsMyocardial InfarctionmenopauseInflammationFibrinogenAsymptomaticcarotid atherosclerosiRisk FactorsInternal medicineOdds RatiomedicineHumansMyocardial infarctionAdverse effectStrokeAgedbiologybusiness.industryC-reactive proteinAge FactorsFibrinogenObstetrics and GynecologyOdds ratioMiddle AgedAtherosclerosismedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareStrokeC-Reactive ProteinCarotid Arteriesinflammationbiology.proteinFemaleRisk factormedicine.symptomTunica IntimaTunica MediabusinessBiomarkersFollow-Up Studiesmedicine.drugMenopause
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Drug-drug interactions in a cohort of hospitalized elderly patients

2013

Purpose The aim of this study is to assess the prevalence of patients exposed to potentially severe drug–drug interactions (DDIs) at hospital admission and discharge and the related risk of in-hospital mortality and adverse clinical events, readmission, and all-cause mortality at 3months. Methods This cross-sectional, prospective study was held in 70 Italian internal medicine and geriatric wards. Potentially severe DDIs at hospital admission and discharge; risk of in-hospital mortality and of adverse clinical events, readmission, and all-cause mortality at 3-month follow-up. Results Among 2712 patients aged 65years or older recruited at hospital admission, 1642 (60.5%) were exposed to at le…

Drugmedicine.medical_specialtyPediatricsMultivariate analysisEpidemiologybusiness.industryClinical eventsmedia_common.quotation_subjectOdds ratioPharmacoepidemiologyConfidence intervalEmergency medicineCohortMedicinePharmacology (medical)businessProspective cohort studymedia_commonPharmacoepidemiology and Drug Safety
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Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review.

2021

Congestion explains many of the signs and symptoms of acute heart failure (AHF) and disease progression. However, accurate quantification of congestion is challenging in daily practice. Antigen carbohydrate 125 (CA125) or mucin 16 (MUC16), a large glycoprotein synthesized by mesothelial cells, has emerged as a reliable proxy of congestion and inflammation in patients with heart failure. In AHF syndromes, CA125 is strongly associated with right-sided heart failure parameters and a higher risk of adverse clinical events beyond standard prognostic factors, including natriuretic peptides. Furthermore, CA125 has the potential for both monitoring and guide HF treatment following a decompensated H…

Heart Failuremedicine.medical_specialtyClinical eventsbusiness.industryDisease progressionCarbohydratesSigns and symptomsmedicine.diseasePrognosisAntigenHeart failureCA-125 AntigenmedicineDisease ProgressionBiomarker (medicine)HumansNarrative reviewIn patientCardiology and Cardiovascular MedicineIntensive care medicinebusinessBiomarkersEuropean journal of heart failureReferences
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